It is highly unlikely testosterone therapy will not to work. Usually, when patients think testosterone therapy is not working, it is because they simply have not given it enough time. While some patients notice improvements within the first few weeks of treatment, particularly in sexual performance, understand that it might take as much as three months of testosterone therapy to find the correct dose for you. However, when working with an experienced doctor and clinic most people start to see significant results. If after that time you still think that your testosterone therapy is not working, you may have to have your dosage adjusted, after additional lab testing, or method of delivery changed from cream to injectable.