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Sermorelin Vs Ipamorelin – Which is Right for You?

  • Both ipamorelin and sermorelin can be used to treat growth hormone deficiencies.
  • A prescription is required for either ipamorelin or sermorelin.
  • Sermorelin and ipamorelin are both growth hormone releasing peptides (GHRP).
  • Sermorelin and ipamorelin stimulate different parts of the brain, but both can boost the release of human growth hormone.
Difference Between Sermorelin and Ipamorelin

Both ipamorelin and sermorelin are used to effectively treat growth hormone deficiencies by stimulating the production and release of HGH.

Technically, both ipamorelin and sermorelin are a type of “growth hormone,” but more accurately they are what is known as GHRPs, or growth hormone releasing peptides, sometimes also referred to as human growth hormone-releasing hormones, (GHRH) or growth hormone releasing factors (GHRF).

While the two GHRPs have much in common, they are not exactly the same thing.

These two drugs have much more in common than they have differences.

What is a Growth Hormone Releasing Hormone?

Growth hormone-releasing hormones or growth hormone releasing peptides such as Ipamorelin and Sermorelin, possess a powerful ability to stimulate the secretion of human growth hormone. They act by reacting with specific receptor cells of the pituitary gland. This is the main purpose of GHRHs as naturally produced by the body – to stimulate the pituitary gland to produce and release human growth hormone (HGH) into the bloodstream. HGH is necessary to not only stimulate and regulate growth in children, but to control metabolism and cellular growth and repair, throughout our lives.

Both ipamorelin and sermorelin are prescription medicationsused to treat men and women who have been diagnosed with sub-optimal levels of growth hormone.

What Is the Difference Between Sermorelin and Ipamorelin?

Sermorelin and Ipamorelin are man-made (synthetic) versions of the GHRH naturally produced by your body. They are prescription medications, used to treat patients with growth hormone deficiencies. Growth hormone-releasing hormones are large peptide hormones that differ from one another only in the number of amino acids, which can vary from 37 to 44. Both ipamorelin and sermorelin are medications that are made to duplicate the action of the naturally occurring GHRH, Ghrelin. Ghrelin is a 28-amino-acid peptide that like ipamorelin and sermorelin acts to increase growth hormone secretion.

Sermorelin is made up of 29 amino acids, therefore its chemical name is GRH 1-29. Ipamorelin is considered to be a somewhat milder GHRP than sermorelin, chemically more similar to Hexarelin and GHRP6.

Both ipamorelin and sermorelin stimulate the secretion of human growth hormone with few if any negative side effects.

As stated above, either sermorelin or ipamorelin can be used to treat low levels of HGH in the blood. Since they both are designed to boost your body’s level of HGH, they effectively have the same benefits. The differences basically lie in the different hormone receptors they react with to stimulate HGH production and release. Because of those different receptors, they can stimulate different volumes of release, over different periods of time. Your doctor will help to decide which one will produce the effects most compatible with your symptoms, goals, and lifestyle. 

The following chart illustrates the differences between the two drugs

Ipamorelin Therapy
Sermorelin Therapy

Ideal age range of patients

Best used for patients from 30 – 50+ or those individuals with low IGF-1 levels

Best used for patients from 30 – 50+ or those individuals with low IGF-1 levels

How many times a day

Once or twice daily depending on specific physician instructions

Once daily at night before bedtime

How long do I have to take (months)

Minimum 9 months and as long as 12 months

Minimum 9 months and as long as 12 months

How long will results last

Once you complete a full nine months of growth hormone therapy, results should last for several months after you last injection.

Once you complete a full nine months of growth hormone therapy, results should last for several months after you last injection.

Approximate cost per month

$400 to $750 per month

$400 to $750 per month

Covered by insurance

Usually not

Usually not

How is it administered

Subcutaneous Injection

Subcutaneous Injection

Do I need a prescription



How Do I Know Which Is Right for Me?

Both sermorelin and ipamorelin therapies are safe and effective, and can effectively treat and in some cases reverse the effects of age-related growth hormone decline.

To sum up, if you believe you are suffering from the negative impacts of low human growth hormone, you really could consider either option.

Speak with your doctor to decide which is right for you, based on your particular needs and lifestyle.

Of the two drugs, sermorelin tends to be slightly more potent in its effects on the body. Ipamorelin is considered to be the more gentle,“gradual”option.

Both sermorelin and ipamorelin have a low risk of side effects, and can be used to treat similar symptoms and problems.

Sermorelin - Ipamorelin Difference

Adverse reactions: rare pain or redness at the injection site. Individual occurrence rates of less than 1% include: headache, dizziness, fatigue and rash.

No severe allergic reactions have been reported with sermorelin.

Contraindications: Neither drug should be used by individuals with a known allergy or sensitivity to the drugs.

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