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What Do Medical Studies Say About Human Growth Hormone?

What Do Medical Studies Say About Human Growth Hormone?

the benefits of growth hormone therapy

Many medical studies have proven the benefits of growth hormone therapy for children, men and women.

Human growth hormone was discovered in the 1920s. Since the 1950s it has been proven in clinical studies to be effective in the treatment of growth hormone deficiency, (GHD) in children who had failed to grow to normal height.

In the decades since, medical research began to look into other uses of human growth hormone (HGH). Specifically, clinical trials were conducted to test the effectiveness of HGH as a hormone replacement therapy for the natural decline of HGH that occurs as men and women age. This age-related HGH decline is responsible for loss of muscle, decreased energy, increased fat, loss of skin elasticity, and many of the other symptoms we think of as “aging.”

In 1990, a landmark medical study into the benefits of HGH therapy for age-related GHD was published. The study was published in the prestigious New England Journal of Medicine, by Daniel Rudman, MD, with the Medical College of Wisconsin. Dr. Rudman studied a group of men aged 61 to 81, who were identified as having low levels of HGH. Using typical double-blind protocols, over the course of six months, half of the men in the study were given HGH injections, the other half, placebo.

The men receiving the HGH clearly showed its benefits. Specifically, these men over the age of 60 saw increased muscle tone, loss of fat, and regenerated skin quality.

In the years since the Rudman clinical study of HGH, HGH has also been extensively studied for its proven beneficial effects on AIDS and on other “muscle wasting” diseases. In clinical studies of HIV/AIDS patients, and more recently in patients with muscular dystrophy, HGH has been shown to slow degeneration of muscle tissue and increase muscle mass. In clinical studies, as well as actual use for patients with HIV/AIDS, HGH has been shown to significantly increase muscle mass, improve strength and energy, and provide higher quality of life, and in many cases, even prolonged longevity.

These successes have led to new avenues of research into the potential anti-aging qualities of human growth hormone.

research into the potential anti-aging qualities of human growth hormone

There has been a long history of clinical research into HGH.

Latest Studies About HGH for Men

Since Dr. Rudman’s breakthrough study of the positive effects of HGH replacement therapy for older men, hundreds of other studies of HGH have been done. Many of these have noted positive effects of HGH injections for the treatment of age-related growth hormone deficiency.

HGH is produced by the pituitary gland. As men age, the ability of the pituitary gland to produce HGH, diminishes. This natural slowdown has triggered human growth hormone studies into HGH as a way to stave off some of the most debilitating symptoms of aging in men, such as decreased muscle and bone mass. Several of these studies on the effectiveness of HGH replacement, have shown that for men who have age-related GHD, injections of HGH can:

  • Increase muscle mass
  • Increase bone density
  • Decrease body fat
  • Increase the ability to exercise, and to get more benefits from exercising

According to a 2018 edition of the Harvard Health newsletter, “Adults with bona fide HGH deficiencies benefit from HGH injections. They enjoy protection from fractures, increased muscle mass, improved exercise capacity and energy, and a reduced risk of future heart disease.”

A 2019 medical study on HGH, published in The World Journal of Men’s Health, concluded that HGH replacement therapy, could increase the lifespan of mice, and potentially of humans, but more research is required.

medical study on HGH

Latest Studies About HGH for Women

There have also been numerous scientific studies into HGH and women. In researching HGH and women, researchers have found that women actually produce more HGH than men. You would think the opposite would be true, that men, because of their larger muscles, would have more HGH than women. However, HGH research has found that women make much more HGH than men. A recent HGH study found out that the reason for this has to do with estrogen. The HGH researchers found that estrogen stimulates greater production of HGH in women than men. The results of this HGH study also mean, therefore, that post-menopausal women are at greater risk of developing age-related GHD than men. As estrogen levels drop after menopause, a woman’s HGH level drops significantly. These clinical studies of women and HGH suggest that women over 60 can benefit even more than men from growth hormone therapy.

Medical research has shown how essential that HGH is to both men and women.

Research Studies on the Effectiveness of Growth Hormone Therapy 

There have been numerous research studies that indicate the effectiveness of HGH injections for treating age-related GHD in men and women.

HGH research studies have found that once we are over the age of 35, we lose about one pound of muscle per year. That loss is directly related to the loss of 1 to 2% of your HGH that also occurs every year after that same age. The symptoms of age-related GHD include:

  • Decreased strength
  • Loss of bone density
  • Loss of lean muscle
  • Increased belly fat
  • Glucose intolerance leading to insulin-resistance and prediabetes
  • Poor skin health
  • Cognitive issues
  • Sexual health issues

Research Studies on the Effectiveness of Growth Hormone Therapy

A search of Pub Med reveals nearly 400 scholarly articles on the positive benefits of growth hormone therapy published between the years 2018 and 2020.

One of the most recent, published in the March 2018 edition of the International Journal of Molecule Science, entitled, Treatment with Growth Hormone for Adults with Growth Hormone Deficiency Syndrome: Benefits and Risks concluded: “Growth hormone replacement exerts unquestionable beneficial effects in many [adult] patients with GHD, and its use is safe for approved indications. [In addition,] HGH has shown beneficial effects on body composition, exercise capacity, bone structure, serum lipids, and quality of life.”

Several studies have indicated the positive benefits of HGH injections for age-related HGH decline.

Now that you know a little bit more about what the medical research says about the many positive benefits of HGH, why not contact us, and find out more about how we may help you with your health and wellness goals.

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Trials Advance to Next Phase for Once Weekly Growth Hormone META: Researchers have announced that they are one step closer to a once weekly, rather than a daily dose, of Human Growth Hormone. Synthetic Human Growth Hormone, or somatropin, is used as a prescription medication to treat several diseases or conditions that prevent children from growing normally. These include: • A brain tumor in the hypothalamus or pituitary • Head trauma • Radiation therapy for cancers, if the treatment field includes the hypothalamus and pituitary • Prader-Willi syndrome • Turner syndrome Growth hormone is also prescribed for the treatment for the weight loss and muscle wasting that occurs in patients with HIV. Growth hormone replacement therapy is also recommended to improve vitality and the quality of life of aging adults suffering from age related growth hormone loss. For the most part, in the treatment of these various conditions, growth hormone is given as a once or twice daily injection. However, at the recent 57th Annual Meeting of the European Society for Pediatric Endocrinology held in Athens, Greece, the results of clinical trial were presented which shows promise for a once weekly prescribed dose of growth hormone. https://www.istockphoto.com/photo/scientist-using-microscope-in-laboratory-gm909176662-250425869 Details of the Clinical Trial for Once Weekly Growth Hormone The study, known as the Real 3 Trial, compared Somapacitan, a novel growth hormone derivative that is currently in development as a once-weekly administration of growth hormone, with Norditropin®, one of the most commonly prescribed versions of somatropin. The trial looked at the effectiveness and therapeutic benefits of each drug used to treat children with growth hormone deficiency, or GHD. The trial compared three different weekly doses of Somapacitan to a 0.034 mg/kg/day dose of Norditropin®. The trial concluded that Somapacitan was well tolerated at all doses investigated, with no clinically relevant safety or local tolerability issues identified. In other words, the once a week injections, proved to be as effective and well-tolerated, as the once daily injections. This is significant because, according to researchers, patients taking daily doses of growth hormone, often experience what is known as “injection fatigue.” “Today children with growth hormone deficiency require daily injections, which can be a considerable treatment burden for patients and caregivers. A once-weekly treatment would represent a significant development for these children and their families, helping them to live less disrupted lives,” said lead investigator Prof Lars Sävendahl of the Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden. In a press release discussing the Real 3 trial, Mads Krogsgaard Thomsen, Executive Vice President and Chief Science Officer of Novo Nordisk, said, "The injection fatigue following years of daily administration could negatively impact adherence, thereby leading to worse treatment outcomes. In line with our long-term commitment, we are investigating the potential of Somapacitan as a once-weekly growth hormone treatment for children with growth hormone deficiency." https://www.istockphoto.com/photo/scientist-doctor-looking-at-sample-in-test-tube-gm863481734-143380883 Other Research Into Growth Hormone Therapy The Real 3 Trial is just one of many ongoing research studies that are looking into better ways to administer growth hormone injections, as well as how to expand the uses of growth hormone. Other interesting trials are looking into the use of growth hormone to treat sports injuries, reduce the risk of strokes, and even extend life! This is only a fraction of the current research into the many positive benefits of growth hormone therapy. From research labs the world over, to the treatment rooms in our own clinics, we are seeing how HGH is changing the lives of many men, women, and children. Why not contact us today, and see how HGH or any of our other hormone therapies may be able to help you. https://www.istockphoto.com/photo/group-of-happy-active-seniors-talking-while-jogging-on-treadmills-in-a-gym-gm941678388-257370836
Trials Advance to Next Phase for Once Weekly Growth Hormone
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